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Results of the AIM-HIGH ( Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes ) [203] and HPS2-THRIVE ( The Heart Protection Study 2Treatment of HDL to Reduce the Incidence of Vascular Events ) [204] studies contributed to a virtual lack of use of niacin in lipid-lowering therapy

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Over-pressuring the vial: Injecting more water volume than the vial can hold creates excess pressure and risks contamination

The rather small sample size limited statistical power, and there was no consideration given to blood loss, iron status, or other clinical factors

Traditionally, the whole bin is incinerated for safety reasons