In these studies, an increase in glutathione reductase activity was thought to suggest an increase of oxidative stress induced by exercise
Studies have uncovered differentially methylated profiles in paternal sperm DNA that is linked with the risk of ASD at birth [102], and the usage of a psychoactive agent, which is also associated with the risk of ASD at birth, can alter DNA methylation patterns on maternally imprinted and ASD candidate genes in the sperm [103]
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On the basis of these biological activities, they were selected as candidate genes for further investigation