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Despite variability across studies, body composition analyses from clinical trials have shown that a relevant proportion of total weight reduction under GLP-1RAs therapy can be attributed to the loss of lean mass, including skeletal muscle [12]

Furthermore, the secretome of hMSC-Ex-4 displayed an altered protein profile, including enhanced secretion of insulin-like growth factorbinding protein 2 (IGFBP2) and apolipoprotein M (APOM), both of which are implicated in metabolic regulation and may contribute to the therapeutic modulation of type 2 diabetes mellitus [18]

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To increase the reliability of the results, we chose several GWAS summary statistics of outcome variables