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In NAFLD, hepatic uptake and de novo lipogenesis are increased, while a compensatory enhancement of fatty acid oxidation is insufficient in normalizing lipid levels and may even promote cellular damage and disease progression by inducing oxidative stress, especially with compromised mitochondrial function and increased oxidation in peroxisomes and cytochromes

Nutt JG, Wooten GF

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To assess the hierarchical cluster tree, we computed the cophenetic correlation coefficient which measures how accurate the clusters reflect the data