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The combination is well-tolerated because cagrilintide targets amylin receptors while semaglutide activates GLP-1 receptors, meaning the mechanisms dont overlap and produce additive effects rather than redundant signalling

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doi: 10.1038/s41586-021-03487-2 32 Le BelleJEHarrisNGWilliamsSRBhakooKK

Analyzing three randomized control trials involving 458 patients, they found that semaglutide was effective at improving histologic and radiologic markers of non-alcoholic steatohepatitis (NASH) activity but not histologic fibrosis