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Studies on diabetic neuropathy, HIV-induced neuropathy, and chemotherapy-related neuropathies highlight its benefits (Onofrj et al., 2013)

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However, this reduced IGFBP binding comes with a pharmacokinetic trade-off: while native IGF-1 circulates with a half-life of 12-15 hours due to IGFBP stabilization, IGF-1 LR3 has a significantly shorter half-life of approximately 20-30 hours

The final product, liraglutide (Victoza, Novo Nordisk), proved its effects in type 2 diabetes mellitus (T2DM) and was approved by the FDA in 2010 [19]

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