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These epidemiologic data underscore an urgent need for pharmacologic interventions that can be instituted long before end-stage disease develops

Moreover, mitochondrial and cytosolic enzymes such as -ketoglutarate dehydrogenase, monoamine oxidase, and glycerol phosphate dehydrogenase are endogenous sources of superoxide anion (O 2 - ) production under pathological conditions [43, 44]

Most of the people prescribing these drugs arent necessarily trained to assess or treat those kinds of risks, he said