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PMID 727443

The quantity, quality, and composition of the food consumed, as well as the timing of meals, directly impact human health by influencing the availability of nutrients

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We selected cell lines originating from different organs known to be targets of metal poisoning, namely, Huh7 (liver, hepatocellular carcinoma), 1321N1 (brain, astrocytoma), U937 (blood, histiocytic lymphoma), HCT116 (colon, carcinoma), and the hTERT-immortalized cell line RPE1 (eye, retinal pigment epithelial cells)

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The phosphodiesterase 4 inhibitor roflumilast augments the Th17-promoting capability of dendritic cells by enhancing IL-23 production, and impairs their T cell stimulatory activity due to elevated IL-10