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doi:10.1007/s11154-014-9289-5 21
Once inside, they mimic the action of the brains own growth factors
However, these models fail to accurately replicate physiological conditions due to their simplified (2D) microenvironment, phenotypic and genetic instability and functional alterations in culture [48]
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Thus, during short-term fasting, changes in free and bioactive IGF-I rather than total IGF-I appear to be at least in part responsible for the increased GH secretion (111, 112), intermittent fasting (113), nor long-term calorie restriction (114) exerts any consistent inhibitory impact on serum IGF-I levels
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