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Systems that relied on estrogen may struggle to adjust: For example, research shows that estrogen plays a crucial role in preserving your bone strength and density, so its decrease may lead to bone loss and eventually, osteoporosis

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Berberine's mechanism involves multiple pathways beyond GLP-1, including direct effects on glucose metabolism, gut microbiota modulation, and inflammation reduction

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whether such a difference between the 2 doses is therefore important in terms of long-term outcomes and diabetic control was not clear from this study