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They also found that in human keratinocytes, apigenin treatment (20 M) had no cytotoxic effects and induced filaggrin, loricrin, aquaporin-3, hyaluronic acid (HA) and HA synthase (HAS)-1, -2, and -3, which constitute physical barrier of the skin [135]

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Macrophages then eat dead cells and release growth signals for new tissue

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