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JAMA Health Forum 2 , e214182 (2021)

In conclusion, semaglutide ameliorates the cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome

As a long-acting peptide containing 34 amino acid residues, Semaglutide presents analytical challenges due to its structural complexity, chemical modifications, and high molecular weight

Additional lipid-lowering agents, such as ezetimibe or icosapent ethyl, may be considered in certain cases

These include chronic stress, poor diet, inadequate sleep, smoking, excessive alcohol consumption, pollution exposure, UV radiation, aging, and intense physical stress

Common side effects include nausea, gastrointestinal disturbance, and injection site reactions