does ghk-cu cause receptor downregulation or tolerance Glycyl‐l‐histidyl‐l‐lysine‐Cu2+ rescues cigarette smoking‐induced skeletal muscle dysfunction via a sirtuin 1‐dependent pathway - Deng - 2023 - Journal of Cachexia, Sarcopenia and Muscle Expression and Purification of Recombinant

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These mechanisms have been demonstrated primarily in laboratory and animal studies

At first glance it looks unusual