1 The management of T2DM is becoming increasingly complex with the availability of more pharmacologic drug classes and the completion of high-quality clinical trials
Importantly, higher amounts of glucose ingested result in more incretin production, which results in more insulin release, more controlled reduction in blood glucose and a lower chance of developing rapid hypoglycemia
Using PET-CT imaging after intravenous administration of 18 F-FDG to T2DM patients treated with metformin, researchers showed that the amount of glucose entering the gastrointestinal system from the circulation was increased, which contributed to the drugs glucose-lowering effect and improved glycemic control (Koffert et al., 2017
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Korosi A, Naninck EF, Oomen CA, Schouten M, Krugers H, Fitzsimons C, et al
Most of the adverse effects patients experience are perceived as mild to moderate and do not lead to discontinuation of the medication