When the same area receives repeated injections, scar tissue and lipodystrophy can develop beneath the skin surface, invisible to the eye but tangible to the touch
Over the past 30years, gastrointestinal hormones have been increasingly understood to have an important role as regulators of appetite and energy balance in obese individuals
106 Additionally, Tanzeum is not suitable for treating type 1 diabetes or diabetic ketoacidosis, related to its pharmacological action and target disease
Zepbound's evidence comes from SURMOUNT-1, also published in NEJM (Jastreboff et al., 2022)
A positive CVOT readout is what unlocks a broad cardiovascular-risk-reduction claim on the eventual label, analogous to what LEADER did for liraglutide and SELECT did for semaglutide
Why are GLP-1 patches advertised