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The triple-agonist mechanism (GLP-1 + GIP + glucagon) produces higher GI rates than semaglutide or tirzepatide alone, with the glucagon receptor being the primary driver of the difference

If you are still on a lower titration dose, your prescriber may recommend continuing to escalate towards the target therapeutic dose before drawing conclusions about efficacy

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While clinical trials show adults on the highest dose of Zepbound lose an average of 22.5% of their body weight after 72 weeks (when paired with diet and exercise), recent Phase 3 trial data (from the TRIUMPH-1 study released in May 2026) shows even better results

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