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Multiple myeloma cells frequently overproduce immunoglobulins subunits and have become the target of the first clinical UPR-targeted therapy to impair ERAD with the proteasome inhibitor, bortezomib (Bross et al

19 4349 10.1038/nm.3023 [DOI] [PubMed] [Google Scholar] Tilg H., Diehl A

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Childress MA, Himmelberg SM, Chen H, Deng W, Davies MA , Lovly CM