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This mechanism is why opioid pain medications commonly cause constipationa well-documented side effect reported in up to 90% of opioid users

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Moving into Phase 3 MariTide is now advancing toward Phase 3 trials, which will evaluate: Long-term safety Real-world outcomes Comparisons with approved agents like Zepbound, Wegovy, and Ozempic Effects on obstructive sleep apnea, heart failure, kidney disease, and other cardiovascular risks Side Effects & Tolerability Like all GLP-1-based medications, MariTide can cause gastrointestinal side effects, especially during dose escalation

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DOI: 10.1210/er.2018-00065 Schumacher A et al

Retinoids (eg, isotretinoin and acitretin) are the most frequent medication-induced cause of chapped lips