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None of these have undergone large-scale trials in humans, and they are not approved drugs

Nutrition interventions for adults with dyslipidemia: a clinical perspective from the National Lipid Association

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A likely explanation for this could be the difference in how the quantification is performed

Enrolled patients have been randomized to one of four weekly treatment arms: VK2735 7.5 mg, 12.5 mg, 17.5 mg, and placebo, a slight amendment from the phase 2 doses, but allowing a higher dose to be examined under a steadier dosing titre than is administered in the phase 2 trial