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The study came out of a curiosity we had, since we certainly are seeing a lot more patients in the clinic on these therapies who are effectively losing weight, he says

The tirzepatide group achieved a mean body-weight reduction of 18%, which appeared greater than that in the placebo group (45)

Although only a small number of cardiomyocytes experience cell death due to apoptosis, activating apoptotic pathways can worsen cardiac dysfunction

Thus, acute treatment may be insufficient to provide clinical improvements in ApoE 4 carriers, with long-lasting stimulation necessary to observe functional benefits [151]

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