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Lixisenatide is a long-lasting GLP-1R agonist that crosses blood-brain barrier at very low doses (Hunter and Holscher, 2012)

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Multi-Receptor Peptide Molecular Formula: CHNO CAS Number: 2381089-83-2 Molecular Weight: ~4730 g/mol Purity: 99.0% (validated by Certificate of Analysis) Appearance: White to off-white lyophilised powder Peptide Length: 39 amino acids Solubility: Soluble in appropriate laboratory solvents Quality Verification: Confirmed by RP-HPLC analytical testing Storage: Store under controlled laboratory conditions Full technical specifications and Certificate of Analysis documentation are available to support laboratory validation and procurement requirements

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The GLP-1RAs@NPs were prepared by vortexing in an acetone solution, then centrifuged at 10,000 rpm for 10 min to obtain the GLP-1RAs@NPs precipitate