4) Long-Lasting Action Unlike endogenous GLP-1, which is rapidly broken down by the enzyme DPP-4, liraglutide can resist enzymatic degradation due to its structural modifications
These should never be present in a sterile injectable product
As a result, it allows multiple uses, while sterile water vial options typically require single-use handling
Consistent with the results in the CM animal model, GLP-1R is completely colocalized with BV-2 microglia, and activation of GLP-1R by liraglutide reduced Iba-1 protein expression and inflammatory factors
Some GLP-1 receptor agonists, like Tirzepatide, have been shown to reduce the risk of major cardiovascular events (e.g., heart attack, stroke) in people with Type 2 diabetes and existing heart disease
Medications that work on 3 different receptors (GLP-1, GIP, and glucagon) are coming down the pipeline