V vy, mc d sn phm c th mang li kt qu ngn hn, ngi dng vn nn cn nhc v cc ri ro tim n trong tng lai
9 Research gaps and future priorities 9.1 Reproductive-oriented RCTs: shifting from metabolic surrogates to hard endpoints To date, most GLP-1RA trials in PCOS have been designed around metabolic efficacy (weight change and insulin-resistance/glycaemic indices) as the primary outcomes, with reproductive outcomesovulation, clinical pregnancy, and live birthreported inconsistently and often as secondary or exploratory measures
Epidemiological analyses reveal a male predominance, with men exhibiting approximately 1.5 times higher risk than women (Ben-Shlomo et al., 2024)
Rekatsina, M
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Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment