Myeloid Trem2 in pro-inflammatory macrophages activates ras-related C3 botulinum toxin substrate 1 (Rac1) through the cyclooxygenase 2/prostaglandin E2 (COX2/PGE2) pathway, promoting the phagocytosis of apoptotic cells accumulated following hepatic ischemia-reperfusion injury in mice, and facilitating macrophage efferocytosis to suppress inflammation (Kwon et al., 2024
Blouw B, Song H, Tihan T, Bosze J, Ferrara N, Gerber H-P, et al
& Nordan, R
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Maturing sperm cells are no stranger to damage from ROS since they are enriched in mitochondria and have walls high in polyunsaturated fats, furthering vulnerability to oxidation
Polar cuticular lipids of workers bind to the Si CSP1 protein, contributing to nestmate recognition, while fatty acids from decaying corpses trigger a necrophoric behavior ( Si CSP1-mediated corpse recognition could compromise nest sanitation efficiency, potentially increasing colony susceptibility to pathogens or reducing social cohesion
