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In the study of endometrial cancer (EC), we found that Brusatol sensitizes the cancer to progestins by inhibiting the NRF2-TET1-AKR1C1 pathway, which reduces AKR1C1 expression and decreases progesterone metabolism [110]

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Understanding these genetic factors can support a conversation with your provider about whether your microbiome is likely to shift significantly during treatmentand whether probiotic adjuncts are warranted

Conditions such as labial melanotic macules are common and usually harmless, but they may cause cosmetic concern

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