Retatrutide is currently in Phase 3 clinical trials (TRIUMPH programme) evaluating long-term efficacy and safety in obesity, type 2 diabetes, and MASH (metabolic dysfunction-associated steatohepatitis) across multiple global sites
Sequence:39-amino-acid synthetic triagonist peptide (fatty-acid-modified) Origin: Engineered triple incretin analogue developed as a single-molecule agonist at GIP, GLP-1 and glucagon receptors
Improvements in liver enzymes accompanied reductions in body weight
For this reason, healthcare providers generally advise against its use during pregnancy until more is known
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