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Amylin itself is a hormone co-secreted with insulin by the pancreas, and it plays a natural role in slowing digestion, controlling appetite, and regulating blood sugar levels

cerebral hypoperfusion induces hypoxia and metabolic stress, activating kinases that hyperphosphorylate tau and accelerate NFT development 74

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In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

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