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This has been discussed for mutualistic interactions: costs, benefits, and thus net effects greatly vary in space and time, affecting geographical disparities in community structures as well as the rate of evolutionary change ( The consequences of context-dependent helpful parasites on host populations and communities have not been studied to the best of our knowledge

FOXO4-DRI breaks this interaction, freeing p53 to initiate apoptosis exclusively in senescent cells leaving healthy cells completely unharmed

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