In a pilot study of 32 migraine sufferers with insulin resistance, supplementation with 400 mg lipoic acid twice daily for six months significantly reduced the number of migraine attacks and days needing treatment, with improvements seen as early as two months (Cavestro 2018)
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Some remain stable longer than others
However, there is also evidence that CYP2E1 function is markedly reduced in this patient population
Given their significance in pharmaceutical testing, this article focuses on GLP regulations in nonclinical laboratory settings