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doi:10.1016/j.peptides.2013.01.014

However, once you add water, the clock starts ticking

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They tracked body mass index (BMI) changes during the first year after treatment began and compared them with later health outcomes through June 2025

Retatrutides activation of the GLP-1 receptor significantly reduces hunger and increases feelings of fullness, enabling caloric intake reduction without discomfort

However, weight isnt an accurate indicator of health, and pathologizing fatness only reinforces fatphobia, diet culture, and healthism