The next section splits these mechanisms into two practical groups: FDA-approved GLP-1 drugs available only by prescription, such as semaglutide and tirzepatide, and non-prescription peptides that work through growth-hormone stimulation or fat-cell targeting instead, such as CJC-1295 and AOD-9604
Like Retatrutide, higher doses provide superior weight reduction, with clinical studies showing up to ~21% weight loss at the highest dose
Studies and clinical trials show that when people stop taking GLP-1s, the appetite often comes back, and in many cases there is rapid weight regain, especially if nutrition and behavior changes werent made when on the medication, she says
High-fat, fried, and very rich foods are the most common triggers for nausea and gastrointestinal discomfort on GLP-1 medications because they slow gastric emptying further on top of the medication's effect
It is stable, inexpensive, and well-absorbed
JAMA 2015;314: 5260