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Keywords: Glucagon-like peptide-1, Glucagon-like peptide-1 receptor agonists, Weight loss, Bone mineral density, Fractures, Microarchitecture, Vitamin D, Calcium intake, Physical activity Introduction Obesity is a global epidemic, as defined by the World Health Organization (WHO), and its prevalence is increasing worldwide

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Resistance training is the top priority

The meta-regression analysis suggested that the apparent protective association of GLP-1RAs may emerge relatively early in treatment, a finding consistent with randomized trials reporting improvements in walking capacity after short-term therapy

This convergence between substance-related and eating-related compulsivity has prompted the use of specific aspects of food preference and intake as proxies for compulsive behaviors in the context of metabolic disease

The logic behind combining these compounds becomes clear when considering the challenge of significant weight loss