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Diabetes Obes Metab (2017) 19:33647

How much does GLP-1 oral cost

The amount of oral intake needed to achieve gastric and intestinal fullness and signal satiety to the brain through the gut-brain axis can overwhelm the evolutionarily determined metabolic capacity of peripheral organs such as liver, pancreas, fat tissue, and muscles

These require immediate medical attention if they occur

Following oral nutrient intake, GLP-1 is secreted from intestinal L-cells located in the ileum and colon

Two things are worth keeping in mind: this was shown in mice and laboratory cells, not yet in humans, and it is a different pathway from the fiber-and-SCFA route below