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NICE guidance (NG23) recommends HRT as first-line pharmacological treatment for women with moderate to severe menopausal symptoms, provided there are no contraindications

The authors proposed that melanocortin signaling may intersect with pigment associated mechanisms involved in oxidative stress buffering, drawing parallels between eumelanin synthesis in melanocytes and neuromelanin accumulation within specific neuronal populations

The original work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License Open Neuroscience Initiative by Austin Lim

The Role of Solute Carriers in the Metabolic Reprogramming of Skin Diseases

Animal studies show no toxicity even at doses 1,000 higher than typical use, but that doesn't mean high doses are risk-free in humans (Sikiric et al., 2014)