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We chose 12.5 hours because germ cell counts became unreliable with longer times (nuclear morphology became increasingly compromised after incubations of 13 hours and longer)
Kidney Int 2000
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doi: 10.1371/journal.pone.0098933 Lipton RB, Stewart WF
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Symptoms of deficiencyfatigue, weakness, paraesthesia, cognitive impairment, and mood disturbancestypically improve significantly with appropriate replacement therapy
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