MIP-1 expression induced by co-stimulation of human monocytic cells with palmitate and TNF- involves the TLR4-IRF3 pathway and is amplified by oxidative stress
In normoglycemic, non-obese rabbits , liraglutide significantly inhibited atherosclerosis progression, with meaningful reductions in percent atheroma volume, plaque macrophage content, cathepsin activity, and systemic CRP
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Lipid profiles and blood pressure markers also showed favorable trends, consistent with the broader GLP-1 drug class
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