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The IBT for all participants consisted of regular behavioral counseling sessions, a restricted-calorie diet, and exercise, building up from 100 to 250 minutes per week

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Average loss was approximately 15% of starting body weight

Both semaglutide and tirzepatide were placed on the FDA's official drug shortage list by 2022, products from two of the world's largest pharmaceutical companies that collectively could not manufacture enough supply to meet what their own commercial teams, and the clinical data, had told them would be a large market

Potential long-term pancreatic risks: recurrent pancreatitis chronic pancreatic inflammation pancreatic exocrine insufficiency increased diabetes risk possible pancreatic fibrosis Though evidence is still evolving, ongoing inflammation could contribute to long-term pancreatic dysfunction