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Kidney problems: May lead to dehydration and worsen kidney function in patients with pre-existing kidney conditions

Background Incretins are gut-derived peptide hormones secreted after nutrient intake to enhance glucose-dependent insulin release from pancreatic -cells

Monitoring thyroid function every three to six months during active GLP-1 therapy, and specifically requesting free T3 along with TSH and free T4, helps catch these shifts early

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Efficacy and Safety of Retatrutide, a Novel GLP-1, GIP, and Glucagon Receptor Agonist for Obesity Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Abdrabou Abouelmagd A

These secondary targets are not interchangeable