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5.4 ApoE and Huntingtons disease (HD) HD is a progressive neurodegenerative disorder caused by a genetic mutation involving the huntingtin gene (HTT), characterized by motor dysfunction, cognitive decline, and psychiatric symptoms (Margolis et al., 2001

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Its research profile centers on mitochondrial retrograde signaling, where the peptide is thought to help regulate how cells adjust energy production in response to metabolic stress, independent of any hormone-receptor cascade

Insufficient levels of treatment do not cause apoptosis but may trigger senescence in cancer cells 20-22

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J Vet Intern Med 32(6):18641873 Prete A, Borges de Souza P, Censi S, Muzza M, Nucci N, Sponziello M (2020) Update on fundamental mechanisms of thyroid cancer