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When exposed to a hyperglycemic milieu, the GIPR was found to downregulate in a study of pancreatic islet cells (59) and the patients with T2DM might express a small amount of GIPR or defective GIPR (60, 61)

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This holistic approach to treatment underscores the importance of addressing both the physical and mental aspects of obesity, paving the way for a more sustainable and fulfilling lifestyle change

The role of GLP-1 RAs was also investigated using the Inverse Probability Treatment Weighting (IPTW) and in the subgroup analyses