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The general guidance based on eGFR is as follows: Normal to mild CKD (eGFR 60+): In this stage, the kidney function is normal or only mildly reduced, and no dose adjustment is required

Behavioral support including counseling, support groups, or working with a registered dietitian can significantly enhance outcomes

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(Contrave is just one tablet with both active ingredients in it.) Your provider will likely start you with one tablet a day of bupropion XL (extended release) and half of a tablet of naltrexone Hcl, and then gradually increase your dosage as needed