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After 36 weeks, the placebo group had lost an average of 2.3%, or 5.3 pounds, compared to 9.4% to 14.7%, or 21.6 to 34 pounds, in the orforglipron groups

Choi KM, Kim JH, Kong X, Isik M, Zhang J, Lim HW, et al

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Clinical trials have demonstrated that it significantly lowers HbA1c levels and promotes substantial weight loss in individuals with type 2 diabetes and obesity