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In response to these concerns, several novel dual or triple agonists have been created based on the structures of gut hormone agonists that are complementary to GLP-1, including glucagon, glucose-dependent insulinotropic polypeptide (GIP), and peptide YY 3-36 (PYY 3-36 ) 6,7,8,9,10,11,12,13,14,15,16,17

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