The FDA is also tracking some adverse event reports that starting GLP-1 treatment caused or exacerbated serious psychiatric conditions associated with depression and suicidality
It reported 10.0% discontinuation for GI symptoms in the semaglutide arm versus 2.0% on placebo with the great majority occurring during the first 20 weeks of dose escalation
Among the largest firms with at least 5,000 workers, 34% say they receive most of the rebates negotiated by their PBM or health plan
Personalization Matters More Than Ever Everyones metabolic state, cholesterol profile, hormone balance, gut health, and risk factors differ
Key facts: Medicaid launch : as early as May 2026 Participation : voluntary for states states must opt in Pricing : CMS negotiates directly with Eli Lilly (Zepbound/Mounjaro) and Novo Nordisk (Wegovy/Ozempic)
References: Ren Y, Chen Y, Zheng W, Kong W, Liao Y, Zhang J, Wang M, Zeng T