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Cutting edge: mTORC2 Regulates CD8+ effector and memory T cell differentiation through serum and glucocorticoid kinase 1

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Downstream IGF-1 Production Increased growth hormone stimulates the liver to produce IGF-1, which mediates many of GH's benefits including tissue repair, muscle protein synthesis, fat metabolism, and cellular regeneration

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Activation of this pathway disturbs lipid synthesis and breakdown, causing abnormal lipid accumulation and metabolic dysfunction in hepatocytes (64)

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