As we observe a correlation between SPHKAP variant effects in T2D and high BMI (as a proxy for obesity), we propose here that SPHKAP might play a pleiotropic role in both disorders by the engagement of common signalling pathways in different tissues
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ChREBP mediates carbohydrate, but not fat-induced DNL as high fat diets do not activate ChREBP and may even decrease ChREBP activity [43, 47]
Read more here: nature.com/articles/s4143 #Ophthalmology With #GLP-1 receptor agonists like semaglutide rising in use for diabetes & obesity, concerns are surfacing about possible ocular side effectsespecially NAION, a serious optic neuropathy