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Among them, SIRT1 is the most studied for its role in fat metabolism, muscle preservation, and mitochondrial health

If heart failure develops, evaluate and manage according to current standards of care and consider discontinuation of JANUVIA

During the ROS production in the polyol pathway, when aldose reductase reduces glucose to sorbitol, excess glucose enters the polyol pathway (Figure 1) (34)

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Tirzepatide, whose main physiological function is as a glucose-dependent insulin nutritive polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor double agonist, is being developed for the treatment of type 2 diabetes and has entered the clinical stage

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