what are glp 1 and gip Major physiological roles of GLP-1 GIP. Tirzepatide is acting as an GLP-1 vs. GLP-1 + GIP:

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Berberine activates AMPK and may improve insulin receptor sensitivity, whilst Wegovy enhances insulin secretion in a glucose-dependent manner and suppresses inappropriate glucagon release

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10.1016/j.mam.2012.05.005 Mol

Top-line results are anticipated in late 2025

This provides a valuable indicator of the extent of kidney damage and, over time, the rate at which kidney function is being lost, and flags the possibility of kidney diseases other than diabetic nephropathy