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Pancreatic islet preparations document the integrated insulinotropic effect of combined GLP-1R and GIPR activation, with glucagon receptor activation providing a counterbalancing signal that researchers can dissect through selective receptor knockout or pharmacological blockade approaches

Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System, Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A, Sikiric S, Bekic D, Soldo D, Grizelj B, Novosel L, Beketic Oreskovic L, Oreskovic I, Stupnisek M, Boban Blagaic A, Dobric I, Pharmaceuticals (Basel), Pharmaceuticals, 2025 Jun 19;18(6):928

The reason for this is not a mystery