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In some cases, maintaining the current dose for a longer period or implementing a more gradual titration schedule may be appropriate

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Carvajal K, Moreno-Snchez R, Elsevier Inc

Specific hereditary backgrounds are implicated, such as FOXP3 pathogenic variants in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and autoimmune regulator (AIRE) mutations in APS type 1 (Klubo-Gwiezdzinska And Wartofsky 2022)

Liu, J., Kang, R

Two multicenter, randomized, double-blind, placebo-controlled Phase III trials enrolled 168 patients with EPP across the United States and European Union